User blog comment:Drakan95/Michael Bay vs Wile E. Coyote. Epic Rap Battles: Cartoons vs History/@comment-26135878-20150611214300

Bruce Banner/The Hulk (even though they started off as a comic, but they're also a cartoon) vs. Dr. Jekyll/Mr. Hyde

Mythbusters vs. Mystery Inc. gang

Ginormica vs. The 50 Foot Tall Woman